Publications

Y.-S. Jang, Ł. Woźniak, J. Pedroni, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI:10.1002/anie.201807749: “Access to P- and Axially-Chiral Biaryl Phosphine Oxides by Enantioselective CpxIrIII-Catalyzed C-H Arylations”

C. G. Newton, E. Braconi, J. Kuziola, M. D. Wodrich, N. Cramer, Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806527: Axially Chiral Dibenzazepinones via a Pd(0)-Catalyzed Atropo-enantioselective C-H Arylation”

J. Diesel, A. Finogenova, N. Cramer, J. Am. Chem. Soc. 2018, 140, 4489-4493: “Nickel-Catalyzed Enantioselective Pyridone C-H Functionalizations Enabled by a Bulky N-Heterocyclic Carbene Ligand”

S.-G. Wang, S. H. Park, N. Cramer, Angew. Chem. Int. Ed. 2018, 57, 5459-5462: A Readily Accessible Class of Chiral Cp Ligands and their Application in Ru(II)-Catalyzed Enantioselective Syntheses of Dihydrobenzoindoles”

S. Miaskiewicz, J. H. Reed, P. A. Donets, C. C. Oliveira, N. Cramer, Angew. Chem. Int. Ed. 2018, 57, 4039-4042: “Chiral 1,3,2-Diazaphospholenes as Catalytic Molecular Hydrides for Enantioselective Conjugate Reductions”

Y. Sun, N. Cramer, Chem. Sci. 2018, 9, 2981-2985: “Tailored trisubstituted chiral CpxRhIII catalysts for kinetic resolutions of phosphinic amides”

2017

D. Grosheva, N. Cramer, ACS Catalysis 2017, 7, 7417-7420: “Ketene Aminal Phosphates: Competent Substrates for Enantioselective Pd(0)-Catalyzed C-H Functionalizations”

Y.-S. Jang, M. Dieckmann, N. Cramer, Angew. Chem. Int. Ed. 2017, 56, 15088-15092: “Cooperative Effects between Chiral CpxIrIII Catalysts and Chiral Carboxylic Acids in Enantioselective C-H Amidations of Phosphine Oxides”

C. G. Newton, D. N. Tran, M. D. Wodrich, N. Cramer, Angew. Chem. Int. Ed. 2017, 56, 13776-13780: “One-step Multigram-scale Biomimetic Synthesis of Psiguadial B”

J. Pedroni, N. Cramer, J. Am. Chem. Soc. 2017, 139, 12398-12401: Enantioselective C–H Functionalization–Addition Sequence Delivers Densely Substituted 3-Azabicyclo[3.1.0]hexanes”

G. Smits, B. Audic, M. D. Wodrich, C. Corminboeuf, N. Cramer, Chem. Sci. 2017, 8, 7174-7179: “A β-Carbon elimination strategy for convenient in situ access to cyclopentadienyl metal complexes”

D. Kossler, F. G. Perrin, A. A. Suleymanov, G. Kiefer, R. Scopelliti, K. Severin, N. Cramer, Angew. Chem. Int. Ed. 2017, 56, 11490-11493: Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes”

D. Kossler, N. Cramer, Chimia 2017, 71, 186-189: “Chiral Cyclopentadienyl Ruthenium Complexes as Versatile Catalysts for Enantioselective Transformations”

C. G. Newton, S.-G. Wang, C. C. Oliveira, N. Cramer, Chem. Rev. 2017, 117, 8908-8976: “Catalytic Enantioselective Transformations Involving C-H Bond Cleavage by Transition-Metal Complexes”

D. Kossler, N. Cramer, Chem. Sci. 2017, 8, 1862-1866: “Neutral Chiral Cyclopentadienyl Ru(II)Cl Catalysts Enable Enantioselective [2+2]-Cycloadditions”

Y. Sun, N. Cramer, Angew. Chem. Int. Ed. 2017, 56, 364-367: “Rhodium(III)-Catalyzed Enantiotopic C-H Activation Enables Access to P-Chiral Cyclic Phosphinamides”

2015

J. Pedroni, N. Cramer, Chem. Commun. 2015, 51, 17647-17657: “TADDOL-based Phosphorus(III)-Ligands in Enantioselective Pd(0)-Catalysed C-H Functionalisations”

D. Kossler, N. Cramer, J. Am. Chem. Soc. 2015, 137, 12478: “Chiral Cationic CpxRu(II) Complexes for Enantioselective Yne-Enone Cyclizations”

C. Heinz, N. Cramer, J. Am. Chem. Soc. 2015, 137, 11278-11281: “Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation”

M. Dieckmann, Y.-S. Jang, N. Cramer, Angew. Chem. Int. Ed. 2015, 54, 12149-12152: Chiral Cyclopentadienyl Iridium(III) Complexes Promote Enantioselective Cycloisomerizations Giving Fused Cyclopropanes”

J. Pedroni, N. Cramer, Angew. Chem. Int. Ed. 2015, 54, 11826-11829: “Chiral Gamma-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations”

J. Pedroni, T. Saget, P. A. Donets, N. Cramer, Chem. Sci. 2015, 6, 5164-5171: “Enantioselective Palladium(0)‐Catalyzed Intramolecular Cyclopropane Functionalizations: Access to Dihydroquinolones, Dihydroisoquinolones and the BMS‐791325 Ring System”

L. Souillart, N. Cramer, Chem. Rev. 2015, 115, 9410-9464: “Catalytic C-C Bond Activations via Oxidative Addition to Transition Metals”

B. Ye, N. Cramer, Synlett 2015, 26, 1490-1495: “Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromames and Phthalides”

L. Souillart, N. Cramer, Chimia 2015, 69, 187-190: “Enantioselective Rhodium-catalyzed C-C Bond Activation of Cyclobutanones”

 

B. Ye, N. Cramer, Acc. Chem. Res. 2015, 48, 1308-1318: “Chiral Cyclopentadienyls: Enabling Ligands for Asymmetric Rh(III)-Catalyzed C-H Functionalizations”

C. M. B. K. Kourra, N. Cramer, Nature 2015, 517, 440-441: “Gold Unleashes the Power of Three, News & Views”

 

L. Souillart, N. Cramer, Chem. Eur. J. 2015, 21, 1863-1867: “Regiodivergent Cyclobutanone Cleavage: Switching Selectivity with Different Lewis Acids”

P. A. Donets, N. Cramer, Angew. Chem. Int. Ed. 2015, 54, 633-637: “Ligand-Controlled Regiodivergent Nickel-Catalyzed Annulation of Pyridones”

2014

M. V. Pham, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 14575-14579: “Rhodium(III)/Copper(II)-Promoted trans-Selective Heteroaryl Acyloxylation of Alkynes: Stereodefined Access to trans-Enol Esters” 

T. Saget, N. Cramer, e-EROS Encyclopedia of Reagents for Organic Synthesis 2014, DOI: 10.1002/047084289X.rn01777: “(1R,7R)-4-Dimethylamino-9,9-dimethyl-2,2,6,6-tetrakis(3,5-dimethylphenyl)-3,5,8,10-tetraoxa-4-phosphabicyclo[5.3.0]decane”

 

M. D. Wodrich, B. Ye, J. F. Gonthier, C. Corminboeuf, N. Cramer, Chem. Eur. J. 2014, 20, 15409-15418: “Ligand-Controlled Regiodivergent Pathways of Rhodium(III)-Catalyzed Dihydroisoquinolone Synthesis: Experimental and Computational Studies of Different Cyclopentadienyl Ligands”

J. S. E. Ahlin, P. A. Donets, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 13229-13233: “Nickel(0)-Catalyzed Enantioselective Annulations of Alkynes and Arylenoates Enabled by a Chiral NHC Ligand: Efficient Access to Cyclopentenones”

L. Souillart, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 9640-9644: “Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation”

J. Pedroni, M. Boghi, T. Saget, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 9064-9067: “Access to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp3)-H Alkylation”

B. Ye, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 7896-7899: “Asymmetric Synthesis of Isoindolones by Chiral Cyclopentadienyl-Rhodium(III)-Catalyzed C-H Functionalizations”

D. N. Tran, N. Cramer, Chem. Eur. J. 2014, 20, 10654-10660: “Biomimetic Synthesis of (+)-Ledene, (+)-Viridiflorol, (-)-Palustrol, (+)-Spathulenol, Psiguadial A, C and D via the Platform Terpene (+)-Bicyclogermacrene”

T. Saget, N. Cramer, Pure Appl. Chem. 2014, 86, 265-272: “Enantioselective Palladium(0)-Catalyzed C-H Arylation Strategy for Chiral Heterocycles”

 

L. Souillart, E. Parker, N. Cramer Top. Curr. Chem. 2014, DOI: 10.1007/128-2013_505: “Asymmetric Transformations via C-C Bond Cleavage”

 

M. V. Pham, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 3484-3487: Aromatic Homologation by Non-Chelate-Assisted RhIII-Catalyzed C-H Functionalization of Arenes with Alkynes”

L. Souillart, E. Parker, N. Cramer, Angew. Chem. Int. Ed. 2014, 53, 3001-3005: “Highly Enantioselective Rhodium(I)-Catalyzed Activation of Enantiotopic Cyclobutanone C-

2012

N. Cramer, Chimia 2012, 66, 869-872: “Teaching Enantioselectivity to C-H Bond Functionalizations: Initial Steps of a Rather Long Shot

T. Saget, N. Cramer, Angew. Chem. Int. Ed. 2012, 51, 12842-12845: Palladium(0)-Catalyzed Enantioselective C-H Arylation of Cyclopropanes: Efficient Access to Functionalized Tetrahydroquinolines”

B. Ye, N. Cramer, Science 2012, 338, 504-506: “Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization”

P. A. Donets, T. Saget, N. Cramer, Organometallics 2012, 31, 8040-8046: “Chiral Monodentate Trialkylphosphines Basing on the Phospholane Architecture”

M. Pham, B. Ye, N. Cramer, Angew. Chem. Int. Ed. 2012, 51, 10610-10614: “Access to Sultams by Rhodium(III)-Catalyzed Directed C-H Activations”

N. Cramer, T. Seiser, “Quaternary Stereogenic Centers by Enantioselective β-Carbon Eliminations from tert-Cyclobutanols” in Asymmetric Synthesis II: More Methods and Applications, (Eds.: M. Christmann and S. Bräse), Wiley-VCH, 2012.

T. Saget, N. Cramer, Chimia 2012, 66, 205-207: “Heteroatom Nucleophile Induced C-C Fragmentations to Access Functionalized Allenes”

T. Saget, S. Lémouzy, N. Cramer, Angew. Chem. Int. Ed. 2012, 51, 2238-2242: “Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)–H Functionalization”

2011

D. N. Tran, N. Cramer Angew. Chem. Int. Ed. 2011, 50, 11098–11102: “Enantioselective Rhodium(I)-Catalyzed [3+2]-Annulations of Aromatic Ketimines Induced by Directed C-H Activations”

B. Winter-Werner, C. Heinis, N. Cramer, Chimia 2011, 65, 818-820 (Conference Report): “The 4th Young Faculty Meeting – Science and Funding in its Different Varieties”

N. Cramer, Chimia 2011, 65, 656-658: “Catalytic Asymmetric Functionalization of Inert Bonds and Synthesis of Bioactive Natural Products”

T. Seiser, T. Saget, D. N. Tran, N. Cramer, Angew. Chem. Int. Ed. 2011, 50, 7740–7752: “Cyclobutanes in Catalysis”

T. Saget, N. Cramer, Synthesis 2011, 2369–2371: “Convenient Preparation of Tri-tert-butylphosphonium Tetrafluoroborate”

D. N. Tran, N. Cramer, Chimia 2011, 65, 271273: “Highly Selective Rhodium Catalyzed Domino C-H Activation / Cyclizations”

N. Cramer, T. Seiser, Synlett 2011, 449-460: “β-Carbon Elimination from Cyclobutanols: A Clean Access to Alkylrhodium Intermediates Bearing a Quaternary Stereogenic Center”

M. Waibel, N. Cramer, Chem. Commun. 2011, 345–348: “Desymmetrizations of meso-tert-norbornenols by rhodium(I)-catalyzed enantioselective retro-allylations” 

2010

T. Seiser, N. Cramer, Angew. Chem. Int. Ed. 2010, 49, 10163–10167: “Rhodium(I)-catalyzed 1,4-Silicon Shift of Unactivated Silanes from Aryl to Alkyl: Enantioselective Synthesis of Indanol Derivatives”

T. Saget, N. Cramer, Angew Chem. Int. Ed. 2010, 49, 8962–8965: “Heteroatom-Nucleophile-Induced C-C Fragmentations: Synthesis of Allenes and Entry to Domino Reactions”

D. N. Tran, N. Cramer, Angew. Chem. Int. Ed. 2010, 49, 8181–8184: “Syn-Selective Rhodium(I)-Catalyzed Allylations of Ketimines Proceeding through a Directed C-H Activation/Allene Addition Sequence”

T. Seiser, G. Cathomen, N. Cramer, Synlett 2010, 1699‒1703: “Enantioselective Construction of Indanones from Cyclobutanols Using a Rhodium-Catalyzed C‒C / C‒H / C‒C Bond Activation Process” 

M. Waibel, N. Cramer, Angew. Chem. Int. Ed. 2010, 49, 4455‒4458: “Palladium-Catalyzed Arylative Ring-Opening Reactions of Norbornenols: Entry to Highly Substituted Cyclohexenes, Quinolines, and Tetrahydroquinolines”

T. Seiser, N. Cramer, Chimia 2010, 64, 153-156: “Enantioselective Rhodium-Catalyzed C-C Bond Activations”

T. Seiser, N. Cramer, J. Am. Chem. Soc. 2010, 132, 5340-5342: “Rhodium-Catalyzed C-C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers”

D. T. Ngoc, M. Albicker, L. Schneider, N. Cramer, Org. Biomol Chem. 2010, 8, 1781‒1784: “Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products”

T. Seiser, N. Cramer, Chem. Eur. J. 2010, 16, 3383-3391: “Rhodium(I)-Catalyzed Enantioselective Activation of Cyclobutanols: Formation of Cyclohexane Derivatives with Quaternary Stereogenic Centers”

2008

T. Seiser,  N. Cramer, Angew. Chem. Int. Ed. 2008, 47, 9294–9297:Enantioselective C-C Bond Activation of Allenylcyclobutanes: Access to Cyclohexenones with Quaternary Stereogenic Centers”

T. Seiser, F. Kamena, N. Cramer, Angew. Chem. Int. Ed. 2008, 47, 6483-6485: “Synthesis and Biological Activity of Largazole and Derivatives”

Postdoc and Graduate Work

B. M. Trost, N. Cramer, S. M. Silverman, J. Am. Chem. Soc. 2007, 129, 12396-12397: “Enantioselective Construction of Spirocyclic Oxindolic Cyclopentanes by Palladium-Catalyzed Trimethylenemethane-[3+2]-Cycloaddition”

B. M. Trost, N. Cramer, H. Bernsmann, J. Am. Chem. Soc. 2007, 129, 3086-3087: “Concise Synthesis of (±)-Marcfortine B”

N. Cramer, S. Helbig, A. Baro, S. Laschat, R. Diestel, F. Sasse, D. Mathieu, C. Richter, G. Kummerlöwe, B. Luy, H. Schwalbe, Chem. Bio. Chem. 2008, 9, 2474–2486: “Synthesis and Biological Properties of Cylindramide Derivatives: Evidence for Calcium-Dependent Cytotoxicity of Tetramic Acid Lactams” 

S. Helbig, S. Sauer, N. Cramer, S. Laschat, A. Baro, W. Frey, Adv. Synth. Catal. 2007, 349, 2331–2337: “Chiral Bicyclo[3.3.0]octa-2,5-dienes as Steering Ligands in Substrate-Dependent Rhodium-Catalyzed 1,4-Addition of Arylboronic Acids to Enones”

T. Ohashi, N. Cramer, T. Ishimizu, S. Hase, Anal. Biochem. 2006, 352, 182-187: “Preparation of UDP-Galacturonic Acid Using UDP-Sugar Pyrophosphorylase”

N. Cramer, S. Laschat, A. Baro, Organometallics 2006, 25, 2284-2291: Chiral Phosphites and Phosphoramidites Based on the Tropane Skeleton and Their Application in Catalysis”

N. Cramer, M. Buchweitz, S. Laschat, W. Frey, A. Baro, D. Mathieu, C. Richter, H. Schwalbe Chem. Eur. J. 2006, 12, 2488-2503: “Total Synthesis and NMR Investigations of Cylindramide”

N. Cramer, S. Laschat, A. Baro, H. Schwalbe, C. Richter, Angew. Chem. Int. Ed. 2005, 44, 820-822: “Enantioselective Total Synthesis of Cylindramide”

N. Cramer, J. Juretschke, S. Laschat, A. Baro, W. Frey, Eur. J. Org. Chem. 2004, 1397-1400: “Acid-Promoted Retro-Mannich Reaction of N-Protected Tropenones to 2-Substituted Pyrroles”

N. Cramer, S. Laschat, A. Baro, Synlett 2003, 14, 2178-2181: “Enzymatic Resolution of Tropinone Derivatives”

N. Cramer, S. Laschat, A. Baro, W. Frey, Synlett 2003, 14, 2175-2177: “Enantioselective Desymmetrization of Tropinone Derivatives by Hydroboration”

R. Ducray, N. Cramer, M. A. Ciufolini, Tetrahedron Lett. 2001, 42, 9175-9178: “Homo-Brook Route to Benzazocenols and Congeners via Allylsilane-Derived Aziridines”